Giardia lamblia growth inhibition by action of the aqueous and methanolic extract of cucurbita pepo seed

  • María Porfiria Barrón González Universidad Autónoma de Nuevo León
  • Ramón Gerardo Rodríguez Garza Universidad Autónoma de Nuevo León
  • Yadira Quiñones Gutiérrez Universidad Autónoma de Nuevo León

Abstract

Giardia lamblia is the protozoan parasite that causes giardiasis, which is characterized by abdominal discomfort, weight loss and malnutrition. The drug of choice for treatment is metronidazole however, presents several adverse side effects in the patient. Moreover, in the herbalist is known seed Cucurbita pepo by desparasitante properties, mainly Entamoeba histolytica and Taenia solium. Therefore it was hypothesized that the seeds of C. pepo contain active substances which inhibit the growth of G. lamblia axenic in vitro conditions. The objective of this study was to evaluate the biological activity of aqueous and methanolic extract of the seeds of C. pepo on the growth of G. lamblia. Both aqueous methanol extract as identified seven functional groups and antioxidant activity was not significant. The methanol extract showed higher aqueous followed giardicida effect, this difference may be due to the saponins found only in the methanol extract. The results suggest that the seeds contain active ingredients that can be used for research into new treatments for giardiasis.

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Published
2015-01-18
How to Cite
Barrón González, M. P., Rodríguez Garza, R. G., & Quiñones Gutiérrez, Y. (2015). Giardia lamblia growth inhibition by action of the aqueous and methanolic extract of cucurbita pepo seed. RIDE Revista Iberoamericana Para La Investigación Y El Desarrollo Educativo, 1(1), 121 - 137. Retrieved from http://mail.ride.org.mx/index.php/RIDE/article/view/18
Section
Medical and Health